Gut microbiota and childhood obesity / 国际儿科学杂志

ABSTRACT

Obesity is a serious public health issue affecting both children and adults. The causes that drive obesity appear to be complex,and a consensus hypothesis is that obesity is influenced by a mixture of envi-ronmental,genetic,and many other factors. Recent evidence suggests that gut microbiota is involved in the con-trol of body weight,energy homeostasis and inflammation,and gut microbiota,plays a role in the pathophysiolo-gy of obesity. Natural delivery,breastfeeding,and early antibiotic resistance are beneficial to maintaining the bal-ance of intestinal microbiota,which may reduce the risk of future obesity. Prebiotics and probiotics may alter the composition of gut microbiota and affect food intake and appetite and body weight. Exploring the relationship be-tween gut microbiota and obesity might provide new methods to prevent and treat children obesity.