Effects of ropivacaine on proliferation,apoptosis and cell cycle of MDA-MB-231 cells / 实用医学杂志
The Journal of Practical Medicine
; (24): 3527-3530, 2017.
Article
in Zh
| WPRIM
| ID: wpr-663732
Responsible library:
WPRO
ABSTRACT
Objective To investigate the effects of ropivacaine on proliferation,apoptosis and cell cycle of MDA-MB-231 Cells. Methods The cultured MDA-MB-231 cells were treated with different concentrations of ropivacaine. The proliferation of MDA-MB-231 cells was detected by MTT method. Cell apoptosis and cell cycle were detected by Annexin V-FITC/PI and flow cytometry. Results After ropivacaine administration,MDA-MB-231 cells proliferation inhibition ratio increased significantly.Annexin V-FITC/PI and flow cytometry showed ropiva-caine had no significant effects on cell apoptosis and cell cycle.Conclusion Ropivacaine can inhibit the prolifera-tion of MDA-MB-231 cells,but can′t induce apoptosis and block cell cycle.
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Index:
WPRIM
Language:
Zh
Journal:
The Journal of Practical Medicine
Year:
2017
Type:
Article