Agreement of HOMA-IR,TyG index and FPG/FIns with GDR in patients with newly diagnosed T2DM / 中国糖尿病杂志

ABSTRACT

Objective To assess the agreement between homeostasis model assessment for insulin resistance index(HOMA-IR),a simple index of fasting serum triglyceride(TG)and plasma glucose(TyG index)and fasting plasma glucose(FPG)/fasting insulin(FIns)with glucose disposal rate(GDR)in patients with newly diagnosed type 2 diabetes(T2DM). Methods A total of 137 patients with newly diagnosed T2DM were enrolled.The levels of FPG,FIns,TG and GDR were measured in baseline. Agreement analysis was performed to assess their agreements. Results The bias and limit of agreement of HOMA-IR,FPG/FIns and TyG index with GDR were - 3.776(- 7.495 ~ - 0.055),- 8.428 (-25.311~ 8.456)and 1.075(- 2.598 ~ 4.749),respectively,and their intra-class correlation coefficients(ICC)were 0.797,0.503 and 0.236,respectively. Conclusion HOMA-IR,TyG index and FPG/FIns showed the acceptable agreement with the GDR. The poor reliability of FPG/FIns and TyG index(ICC＜0.6)limits its clinical application.