The regulatory role of cerebellar degeneration-related protein 1 antisense / 中国医师进修杂志
Chinese Journal of Postgraduates of Medicine
; (36): 82-85, 2018.
Article
in Zh
| WPRIM
| ID: wpr-665884
Responsible library:
WPRO
ABSTRACT
Circular RNA is a kind of single-stranded RNA ring without 5'capping and 3'polyadenylation.As a new member of non-coding RNA, circular RNA is evolutionally conserved, relatively stable,highly specific and enormously abundant.Instead of liner RNA,circular RNA became the research hotspot.So far,cerebellar degeneration-related protein 1 antisense(CDR1as)is a molecule that has garnered intense research.CDR1as harbors 74 conventional miRNA-7 binding sites.Expression of CDR1as efficiently tethers micro RNA-7, resulting in reduced micro RNA-7 activity and increased levels of micro RNA-7 targeted transcripts consistent with the micro RNA sponge and competing endogenous RNA(ceRNA)hypothesis.Moreover,CDR1as can restore micro RNA-7 and release it at right time.CDR1as can be stabilized in the exosomes.And its level has correlation with many clinical characteristics.
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Postgraduates of Medicine
Year:
2018
Type:
Article