Effect of different additive ingredients on the activity of adipocytes: research progress and application status / 中国组织工程研究

ABSTRACT

BACKGROUND: Autologous adipose tissue has become an ideal filling material due to the fact that it has no rejection reaction, but has abundant source, good texture and appearance after transplantation, and low cost.OBJECTIVE: To review the research advance in the effect of different additive ingredients on the activity of adipocytes.METHODS: A computer-based retrieval of CNKI, WanFang, VIP, PubMed, Elsevier, and Embase databases was conducted for the articles about adipocyte viability using the keywords of "autologous adipose tissue, rate of survival,stromal vascular fraction, platelet-rich plasma, growth factor, adipose derived stem cells, leptin" in English and Chinese,respectively. Finally 47 eligible articles were included for further analysis.RESULTS AND CONCLUSION: Autologous fat transplantation still holds some limitations. It has been found that the survival rate of single autologous fat globules is less than 60%. The high absorption rate of adipose tissues, cyst,calcification and other complications after transplantation restrict its far-ranging application. In order to improve the survival rate of transplanted adipose tissues, most of scholars have been trying to improve the method of liposuction,cryopreservation conditions, or add different ingredients such as platelet-rich plasma and stromal vascular fraction. The stromal vascular fraction, platelet rich plasma, adipose derived stem cells, botulinum toxin A, and some cytokines have been confirmed to be feasible and effective according to a series of trials; however, the studies on leptin and some other kinds of cytokines and drugs still in the experimental stage, which need to be explored in depth.