The effect of rhBMP2 used as a indirect pulp capping agent / 实用口腔医学杂志

ABSTRACT

Objective: To investigate the reparative dentine formation induced by the recombinant human bone morphorgenetic protein2(rhBMP2) used as a indirect pulp capping agent in dog teeth. Methods: Type V cavities were prepared in 48 teeth of 2 dogs. rhBMP2 with zinc oxide(A) was lined on the bottom of 24 cavities, saline with zinc oxide(B) in 12 and zinc oxide eugentol cement(C) in 12. 0.5 g of tetracycline was orally administered to the dogs twice a day on day 24, 54, 83 and 111. On day 135, the teeth were extracted and processed for the quantitative observation of reparative dentin under a fluorescent microscope .Results: On day 135, the reparative dentine (expressed as "?m" of diameter of area) in group A, B and C was 825.04? 125.46, 315.33? 80.43 and 415.25? 90.75 respectively(P