Cerulenin induces apoptosis of the cells in oral squamous cell carcinoma / 实用口腔医学杂志
Journal of Practical Stomatology
; (6)2000.
Article
in Zh
| WPRIM
| ID: wpr-670645
Responsible library:
WPRO
ABSTRACT
Subjective To observe apoptosis of the cells in oral sq uamous cell carcinoma(SCC) induced by cerulenin. Methods:
SCC TCA-83 cells and fresh tissue of SCC of tongue from 5 patients were expos ed to cerulenin (10 mg/ml) for 24 hours, then the genosome DNA of the cells was extracted and electrophoresed; the fresh tissue of SCC was assessed by TUNEL labeling.Results:
DNA gel electrophoresis showed typical apoptic DNA ladders from TCA-83 cells. The rate (%) of TUNEL-positive cells in cerulenin treated tissue of SCC was 29.0?2.6~40.6?16.2,that in the control 2 . 0?1.7~14.7?0.6 (P
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Index:
WPRIM
Language:
Zh
Journal:
Journal of Practical Stomatology
Year:
2000
Type:
Article