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Pulmonary Toxicity of Three Typical Nanomaterials Caused by Intratracheal Instillation in Rats / 环境与健康杂志
Article in Zh | WPRIM | ID: wpr-676844
Responsible library: WPRO
ABSTRACT
Objective To investigate the toxic effect of nona-ferroso-ferric oxide(Nano-Fe_3O_4),nano-silicon dioxide(Nano- SiO_2)and single walled carbon nanotubes(SWCNTs)on the lung and mechanism in rats.Methods Fourty-nine Wistar rats were randomly divided into 7 groups,the control group,low and high dose groups of three nanomaterials.The rats were exposed by intratracheal instillation once two days for 5 weeks,and then killed by abdominal aorta bloodletting.The pathology of lung,lactate dehydrogenase(LDH),total antioxidant capacity(T-AOC),superoxide dismutase(SOD),malondialdehyde(MDA),interleukin-1(IL- l),interleukin-6(IL-6)and tumor necrosis factor-?(TNF-?)in bronchoalveolar lavage fluid(BALF)were determined.Results The fibrous tubercle and the matrix inflammation of lung tissue was found in the experimental groups.The activities of T-AOC and SOD decreased while IL-6 concentration increased significantly in the experimental groups(P
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Full text: 1 Index: WPRIM Language: Zh Journal: Journal of Environment and Health Year: 2007 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Journal of Environment and Health Year: 2007 Type: Article