Effects of ginkgo biloba extract on expressions of NSE S-100 mRNA in newborn rat brain with hypoxic-ischemic brain damage / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)1987.
Article
in Zh
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| ID: wpr-678044
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ABSTRACT
ALM To study the effects of ginkgo biloba extract (GbE) on expressions of neuron specific enolase (NSE) and S 100 protein(S 100) mRNA in newborn rat brain after hypoxic ischemic brain damage (HIBD) and the mechanism of GbE against HIBD. METHODS The dynamic changes of expressions of NSE S 100 mRNA in brain tissue and effects of GbE were studied using 7 d SD rat hypoxic ischemic brain damage model and RT PCR techniques. RESULTS The peak expressions of mRNA for NSE and S 100 occurred 24 and 48 hours after HIBD respectively, and their expressions decreased gradually. The expressions of mRNA for NSE S 100 in 24, 48, 72 hours were increased after treatment with GbE ( P
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WPRIM
Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
1987
Type:
Article