Effect of morphine on the changes of intracellular free calcium in cultured hippocampal astrocytes in rat / 第三军医大学学报
Journal of Third Military Medical University
; (24)1983.
Article
in Zh
| WPRIM
| ID: wpr-678092
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WPRO
ABSTRACT
0.05). Spike of [Ca 2+ ]i of astrocytes was induced by acute morphine administration, but the spike of [Ca 2+ ]i of astrocytes pretreated with morphine could be induced only by higher concentration of morphine. The [Ca 2+ ]i response of astrocytes to morphine could be blocked by naloxone but not by MK 801(NMDA receptor antagonist). Conclusion The response of [Ca 2+ ]i in morphine induced astrocytes may play an important role in morphine tolerance.
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Language:
Zh
Journal:
Journal of Third Military Medical University
Year:
1983
Type:
Article