Tetrasomy 8 in a Patient with Acute Monoblastic Leukemia / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 262-266, 2008.
Article
in English
| WPRIM
| ID: wpr-67876
ABSTRACT
Trisomy 8 is one of the most frequent numerical chromosomal abnormalities observed in hematological malignancies, whereas tetrasomy 8 is a clonal aberration seen mainly in myeloid disorders such as acute myelod leukemia (AML) and myelodysplastic syndromes. In contrast to trisomy 8, tetrasomy 8 is a rare chromosomal aberration, in that only 17 reported AML cases with isolated tetrasomy 8 have been documented. Interestingly, the majority of reported cases were associated with monocytic-lineage leukemias. According to recent reports, tetrasomy 8 is regarded as a poor prognostic factor, and most patients having this abnormality relapsed and died within 1 yr. Here, we report a patient with acute monoblastic leukemia having tetrasomy 8 and a very aggressive disease course.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Chromosomes, Human, Pair 8
/
Leukemia, Monocytic, Acute
/
In Situ Hybridization, Fluorescence
/
Karyotyping
/
Aneuploidy
Type of study:
Prognostic study
Limits:
Humans
/
Male
Language:
English
Journal:
The Korean Journal of Laboratory Medicine
Year:
2008
Type:
Article
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