The experimental study on radioguided surgery in lung carcinoma using ~(18)F-FDG / 解放军医学杂志

ABSTRACT

Objective To investigate the effectiveness of radio gu ided surgery (RGS) in lung carcinoma by using ~18F-FDG. Methods Forty mice bearing lung adenocarcinoma were divided randomly into two gro ups according to presence or absence of the lung metastasis. A dose of 200?l (1 00?Ci) of ~18F-FDG was injected via the tail vein. The external radioimmu nography was performed after injection. All viscerae and tumor were detected i n vivo by means of a hand-held gammaray-detecting probe (GDP), and the radio active distribution was analyzed with the well-gammaray detector. Resul ts The tumor images in mice were clear, and the images were best at two hours after injection. The values of %ID/g of tumor and heart obtained by well -gammaray detector were higher than those of other organs. Ratios of tumor/norm al tissue (T/NT) except cardiac muscle being detected by GDP ranged from 3.71 t o 13.57. There was a significant difference between the radioactivity of lung t issues in lung metastasis group and that of control group (P