PDTC reduces E-selectin expression on hypoxia/reoxygenation-stimulated endothelial cells / 中华胸心血管外科杂志
Article
in Zh
| WPRIM
| ID: wpr-682400
Responsible library:
WPRO
ABSTRACT
Objective:
To study the mechanisms and treatment of ischemia/reperfusion injury. Expression of E selectin was measured and the effect on suppression of E selectin by the Pyrrolidine Dithiocarbamate was investigated.Methods:
Endothelial cells were exposed to hypoxia, then returned to reoxygenation condition. ELISA methods were used to detect expression of E selectin.Results:
E selectin expression on hypoxia/reoxygenation stimulated endothelial cells increased, PDTC could suppress translation of E selectin effectively.Conclusion:
It seems that E selectin may act as a critical factor. PDTC may prove beneficial in the treatment of ischemia/reperfusion injury.
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Thoracic and Cardiovascular Surgery
Year:
2003
Type:
Article