The experimental study of 5-FU on inhibiting angiogenesis / 医学研究生学报

ABSTRACT

Objective:To investigate the antiangiogenesis ability of 5 FU. Methods:Human umbilical vein endothelial cells were cultured primarily in vitro and influence of 5 FU on HUVEC proliferation was evaluated by MTT method. Chick chorilallantoic membranes(CAM) model was used to check whether the neovascularization of CAM could be suppressed in vivo . Results:5 FU both inhibited proliferation of HUVEC in vitro and suppressed angiogenesis of CAM in vivo at none cytotoxic doses. Conclusion: 5 FU demonstrated antiangiogenesis ability without obvious cytotoxicity.