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Molecular mechanisms underlying daptomycin resistance / 生物工程学报
Chinese Journal of Biotechnology ; (12): 832-838, 2018.
Article in Zh | WPRIM | ID: wpr-687733
Responsible library: WPRO
ABSTRACT
Due to potent bactericidal activity and low rate of drug-resistance, daptomycin is recognized as first line antibiotic to treat serious infections caused by drug-resistant Gram-positive pathogens. However, the incidence of daptomycin resistance is increasing due to its widespread application. Alteration of cell wall homeostasis and membrane phospholipid metabolism is involved in daptomycin resistance. The unique mode of action underlying daptomycin resistance in important pathogens, including Staphylococcus aureus and Enterococci, is presented in this paper.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Journal of Biotechnology Year: 2018 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Journal of Biotechnology Year: 2018 Type: Article