Correlation of 41 loci of single nucleotide polymorphisms with testicular germ cell tumor / 中华男科学杂志
National Journal of Andrology
; (12): 602-607, 2018.
Article
in Zh
| WPRIM
| ID: wpr-689713
Responsible library:
WPRO
ABSTRACT
<p><b>Objective</b>To identify genetic susceptibility genes and the loci of their single nucleotide polymorphisms (SNPs) in patients with testicular germ cell tumor (TGCT) and provide some new ideas for the prediction, diagnosis and treatment of TGCT.</p><p><b>METHODS</b>We identified 41 SNP loci of TGCT-related genetic susceptibility genes from the literature published abroad. Using the iMLDRTM genotyping technique, we examined the SNP loci of the genetic susceptibility genes in the blood samples from 76 TGCT patients (aged 16-68 years) and 148 healthy men (aged 22-61 years) in China and analyzed their correlation with TGCT.</p><p><b>RESULTS</b>In China, TGCT was found to be correlated with the SNP loci rs2978381, rs10146204, rs12435857 and rs1256063 of the ESR2 gene, rs9397080 of the ESR1 gene, rs11202586 of the PTEN gene, rs2606345 and rs4646903 of the CYP1A1 gene, and rs1456432 of the CYP19A1 gene.</p><p><b>CONCLUSIONS</b>The results of our study indicated some difference in the positive SNP loci of the TGCT patients between Chinese and foreign cohorts as well as in different groups in China.</p>
Key words
Full text:
1
Index:
WPRIM
Main subject:
Testicular Neoplasms
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Therapeutics
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Case-Control Studies
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China
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Neoplasms, Germ Cell and Embryonal
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Genetic Predisposition to Disease
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Polymorphism, Single Nucleotide
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Diagnosis
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Genetics
Type of study:
Diagnostic_studies
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Observational_studies
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Risk_factors_studies
Limits:
Adolescent
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Adult
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Aged
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Humans
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Male
Country/Region as subject:
Asia
Language:
Zh
Journal:
National Journal of Andrology
Year:
2018
Type:
Article