Impact of inhaled anesthetics on the male reproductive system and its mechanisms: An update / 中华男科学杂志
National Journal of Andrology
; (12): 272-276, 2018.
Article
in Zh
| WPRIM
| ID: wpr-689764
Responsible library:
WPRO
ABSTRACT
The safety of occupational exposure to inhaled anesthetics remains a concern among the medical staff in hospitals. Few reports are seen about the impact of inhaled anesthetics on the reproductive system, particularly that of males. Several clinical and basic studies on isoflurane and others suggest that inhaled anesthetics affect the reproductive system of rodents by decreasing the sperm count, inducing sperm morphological abnormality, reducing sperm motility, and changing the levels of reproductive hormones, the underlying mechanisms of which are mainly associated with the alteration of the hypothalamic-pituitary-gonadal axis and DNA damage and apoptosis of reproductive cells. This article reviews the main impacts of inhaled anesthetics on the male reproductive system and the possible mechanisms.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Sperm Count
/
Sperm Motility
/
Spermatozoa
/
DNA Damage
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Occupational Exposure
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Apoptosis
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Anesthetics, Inhalation
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Genitalia, Male
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Isoflurane
Limits:
Humans
/
Male
Language:
Zh
Journal:
National Journal of Andrology
Year:
2018
Type:
Article