Molecular Characterization and Correlation with β-lactam Resistance of Streptococcus pneumonia Isolates in Hangzhou, China / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 389-393, 2018.
Article
in En
| WPRIM
| ID: wpr-690645
Responsible library:
WPRO
ABSTRACT
Penicillin-binding proteins (PBPs) are the target of β-lactam antibiotics (the major treatment for Streptococcus pneumoniae infections), and mutations in PBPs are considered as a primary mechanism for the development of β-lactam resistance in S. pneumoniae. This study was conducted to investigate the mutations in the PBPs of clinical S. pneumoniae isolates in Hangzhou, China, in correlation with β-lactam resistance. Results showed that 19F was the predominant serotype (7/27) and 14 of the S. pneumoniae isolates were resistant to both penicillin G and cephalosporin. Genotyping results suggested that β-lactam-resistant isolates primarily exhibited single-site mutations in both the STMK and SRNVP motifs of pbp1a in combination with double-site mutations in the STMK motif of pbp2x, which might be the primary mechanisms underlying the β-lactam resistance of the isolates in this study.
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Pneumococcal Infections
/
Streptococcus pneumoniae
/
China
/
Epidemiology
/
Drug Resistance, Bacterial
/
Beta-Lactams
/
Genetics
/
Microbiology
/
Anti-Bacterial Agents
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Biomedical and Environmental Sciences
Year:
2018
Type:
Article