Progresses in genetics of coronary artery lesion in Kawasaki disease / 国际儿科学杂志

ABSTRACT

Kawasaki disease (KD)also known as mucocutaneous lymph node syndrome is a systemic vascular disease without clear etiology.KD mainly occurs in infants and children under the age of five.Coronary artery lesion(CAL) is the most important factor affecting the prognosis of KD patients.It is the main cause of childhood ischemic heart disease,including coronary artery dilatation,coronary aneurysm and coronary artery stenosis.So far,more and more researches indicate that genetic factors play a significant role in the pathogenesis of KD with coronary artery injury.This article focuses on the progress of gene polymorphism in KD with coronary artery injury.