Relationship between Klotho gene and growth axis GH-IGF1 / 国际儿科学杂志

ABSTRACT

Klotho was first discovered as an aging-suppressor gene. Klotho protein is highly expressed in the brain and the kidney,but can also serve as a circulating hormone. Evidences suggest that Klotho is involved in calcium phosphate homeostasis,energy metabolism,protection of the cardiovascular system,protection of kid-ney and anti-aging through membrane receptors and hormone-like effects. Currently available studies support a tight interaction between Klotho and the GH-IGF1 axis,with a complex reciprocal regulation between them. On one hand,increased activity of the GH-IGF1 axis upregulates serum Klotho levels,which in turn inhibits the pe-ripheral activity of IGF1,thus forming a negative feedback loop. On the other hand,klotho abrogates the inhibito-ry effect of IGF1 in the pituitary,leading to enhanced GH secretion and further increase of IGF1 production,thus forming a positive feedback loop. In addition,Klotho plays an important role in calcium- phosphate metabolism together with GH-IGF1 and FGF23. In this paper,the regulation of Klotho expression and its relationship with GH-IGF1 axis and mineral metabolism are reviewed briefly.