Correlation analysis of Aldehyde dehydrogenase 2 genetic Glu504Lys polymorphism and hypertension in chongqing area / 国际检验医学杂志

ABSTRACT

Objective To study the acetaldehyde dehydrogenase 2(ALDH2)Glu504Lys polymorphism and the correlation of hypertension in Chongqing area.Methods The ALDH2 genotype of 144 patients hyperten-sion group and 193 healthy people controls group were detected by gene chip.Results Three types of ALDH2 genotypes were detected,which were ALDH2*1/*1(wild type),ALDH2*1/*2 and ALDH2*2/*2(mu-tant).The wild type and mutant type in hypertension group and control group were 112(77.78%),32 (22.22%)and 114(59.07%),79(40.93%)respectively,distribution accorded with Hardy-Weinberg equilibrium.The wild type ratio of hypertension group was higher than that of the control group,and the difference was statistically significant(P<0.05).Logistic regression analysis showed that ALDH 2 gene poly-morphism was an independent risk factor for hypertension.Conclusion The ALDH2 wild type in chongqing is closely related to hypertension.