Vascular endothelial growth factor: a potential therapeutic target for ischemic stroke / 国际脑血管病杂志

ABSTRACT

Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis and vascular regeneration after cerebral ischemia.On one hand,VEGF plays a neuroprotective effect by promoting angiogenesis and neurogenesis;on the other hand,VEGF induced endothelial permeability can cause blood-brain barrier (BBB) dysfunction.Exercise preconditioning can up-regulate the expression of VEGF and reduce the ischemic brain damage by enhancing the cerebral microvascular integrity.VEGF can be used as a therapeutic target for ischemic stroke.