Influence of different types of cell senescence on the development and progression of liver fibrosis / 临床肝胆病杂志

ABSTRACT

Cell senescence is a basic cell response triggered by various stimuli and is a basic characteristic of living organism. Liver fibrosis refers to the pathological process of diffuse excessive deposition of extracellular matrix in the liver caused by abnormal proliferation of connec-tive tissue due to various pathogenic factors and can progress to liver cirrhosis and liver cancer. Studies have shown that cell senescence is closely associated with the progression of liver fibrosis. This article reviews the regulatory effect of different types of cell senescence on liver fibrosis.