Acute eosinophilic leukemia transformed from myelodysplastic syndrome: a case report and literature review / 临床检验杂志
Chinese Journal of Clinical Laboratory Science
; (12): 235-238, 2018.
Article
in Zh
| WPRIM
| ID: wpr-694827
Responsible library:
WPRO
ABSTRACT
Objective To summarize and explore the morphological characteristics,genetic alterations,immunophenotype and characteristics of molecular marker of acute eosinophilic leukemia (AEL),and improve the awareness for AEL.Methods A case of refractory hematopoietic dysplasia (MDS-RCMD) transformed to AEL in our hospital was retrospectively reviewed.Results The MDS-RC-MD patient transformed to AEL in 12 months after diagnosis.In his special bone marrow 10.4% was blasts,while 70.8% of bone marrow cells were eosinophils including 69.3% of promyelocyte,myelocyte and metamyelocyte.Eosinophils accounted for 13.5% in his peripheral blood.The blasts in bone marrow expressed CD34,CD117,HLA-DR,CD33,CD38 and CD13,and accompanied by complex chromosomal abnormalities.FI1L1/PDGFRα and ETV6/PDGFRβ fusion gene were negative.The patient died two months later following treating with AML regimen.Conclusion The AEL patient with negative FI1L1/PDGFRα and ETV6/PDGFRβ gene rearrangement,imatinib treatment is ineffectual.
Full text:
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Index:
WPRIM
Type of study:
Prognostic_studies
Language:
Zh
Journal:
Chinese Journal of Clinical Laboratory Science
Year:
2018
Type:
Article