Expression of Orai1 and STIM1 protein in colon cancer and their clinical significance / 临床与实验病理学杂志

ABSTRACT

Purpose To investigate the expression of Orai1 and STIM1 in colon cancer and its clinical significance.Methods Immnohistochemistry was used to detect Orai1 and STIM1 protein expression level in 80 cases of colon cancer and 50 cases of normal colon epithelium.The relationships between Orai1 and STIM1 expression and prognosis were statistically analyzed.Result The expression levels of Orai1 and STIM1 in colon cancer were significantly higher than that in normal colon epithelium(P＜ 0.05).Positive expression of Orai1 and STIM1 was correlated with the TNM stage and lymph node metastasis (P ＜ 0.05),but not correlated with gender,age,and differentiation(P ＞0.05).There was a significant positive correlation between Orai1 and STIM1 expression(P =0.001,rs =0.349).Univariate analysis showed that the expression of Orai1 protein,STIM1 protein,TNM stage and lymph node metastasis were significant prognostic factors for colon cancer patients.Conclusion In colon cancer,both Orail and STIM1 proteins may have synergetic functions and promote the development of the tumor,and could be used as a novel biological indicator of anticancer therapy and prognosis.