Preliminary screening and study of novel flavonoid monoacylglycerol lipase inhibitors / 上海交通大学学报(医学版)
Journal of Shanghai Jiaotong University(Medical Science)
; (12): 30-35, 2018.
Article
in Zh
| WPRIM
| ID: wpr-695608
Responsible library:
WPRO
ABSTRACT
Objective·To discover and develop novel monoacylglycerol lipase (MAGL) inhibitors.Methods·Computational screening,rational structure analysis and biological assessment was used.Results·A series of natural flavonoid MAGL inhibitors were identified.Compound 9 (quercetin) presented the highest activity with an IC50 value of 36 μmol/L.Conclusion·Several natural flavonoid MAGL inhibitors were identified,which are expected to bring novel hits for discovery ofMAGL inhibitors.
Full text:
1
Index:
WPRIM
Type of study:
Diagnostic_studies
/
Screening_studies
Language:
Zh
Journal:
Journal of Shanghai Jiaotong University(Medical Science)
Year:
2018
Type:
Article