The association study on ABO blood types and prognosis of patients with ovarian cancer / 天津医药

ABSTRACT

Objective To explore the influence of ABO blood type and other related factors on the prognosis in patients with ovarian cancer. Methods The clinical and pathological data and ABO blood types of 153 patients with ovarian cancer who were undergone radical surgery from December 2007 to July 2011 in Tianjin Medical University Cancer Institute and Hospital were retrospectively analyzed. Among them, there were 45 cases (29.4％) of blood type A, 43 cases (28.1％) of type B, 50 cases (32.7％) of type O, and 15 cases (9.8％) of type AB. The clinical characteristics of patients with different blood group types were analyzed, and the patients were followed up (the last follow-up time was June 2017). Kaplan-Meier method was used to draw the survival curve, and the Log-rank method was used to compare the differences between the total survival and disease-free survival rates in different blood groups. Cox regression analysis was performed to explore the prognostic factors in patients with ovarian cancer. Results (1) There were no statistically significant differences in the clinical features of different blood types, such as age, menstrual condition, recurrence, metastasis, clinical staging, CA-125 level, and adjuvant treatment (P>0.05). (2) The total survival rate and disease-free survival rate were significantly higher in patients of O and B blood types than those in patients of A and AB blood types (Log rank χ2=9.571 and 8.213 respectively, all P<0.05). Cox regression analysis showed that ABO blood group type was an influential factor in the prognosis of ovarian cancer patients, and patients with AB blood group showed a poorer prognosis (type B vs. type AB HR=0.339, 95％CI0.138-0.830, type O vs. type AB HR=0.343, 95％CI0.137-0.855). Conclusion ABO blood type is related to the survival of ovarian cancer patients, and which can be used to evaluate the prognosis in patients of ovarian cancer.