Relationship among serum levels of hsCRP ,MCP-1 ,CTRP9 ,APN ,Lp-PLA2 ,Fractalkine , regulated on activation ,normal T-cell expressed and secreted and asymptomatic coronary atherosclerosis / 心血管康复医学杂志

ABSTRACT

Objective :To explore relationship among serum levels of high sensitive C reactive protein (hsCRP) ,mon-ocyte chemoattractant protein (MCP )-1 , C1q/tumor necrosis factor-related protein (CTRP ) 9 , adiponectin (APN) ,lipoprotein-associated phospholipase (Lp-PLA) 2 ,Fractalkine (namely , chemotatic factorCX3C) , regu-lated on activation , normal T-cell expressed and secreted (RANTES ) and asymptomatic coronary atherosclerosis (ACAS).Methods : A total of 50 ACAS patients ,who were treated in our hospital from Dec 2015 to Dec 2016 ,were re-garded as ACAS group.Another 50 healthy subjects were enrolled as normal control group .Serum levels of hsCRP ,MCP-1 ,RANTES ,CTRP9 ,APN ,Lp-PLA2 and Fractalkine were measured and compared between two groups .Results : Com-pared with healthy control group ,there were significant reductions in serum levels of CTRP9 [(3.70 ± 1.20) 10－2mg/L vs. (3.19 ± 1.11) 10－2mg/L] and APN [ (3.85 ± 1.15) mg/L vs.(3.28 ± 1.01) mg/L] ,and significant rise in serum levels of hsCRP [ (32.55 ± 1.55) mg/L vs.(110.47 ± 1.53) mg/L] ,MCP-1 [ (480.22 ± 5.38) pg/ml vs.(600.47 ± 5.43) pg/ml] ,RANTES [ (2.80 ± 0.20) μg/ml vs.(4.19 ± 0.22) μg/ml] ,Lp-PLA2 [ (165.88 ± 5.32) mg/L vs.(199.55 ± 5.35) mg/L] and Fractalkine [(322.40 ± 5.60) pg/ml vs.(500.64 ± 5.66) pg/ml] in ACAS group ,P＜0.05 or ＜0.01. Conclusion :Compared with normal control group ,there are significant reductions in serum levels of CTRP9and APN ,and significant rise in serum levels of hsCRP ,MCP-1 ,RANTES ,Lp-PLA2 and Fractalkine in ACAS patients .Detection of a-bove indexes can provide strong evidence for early diagnosis and intervention .