Efficacy of tigecycline- based treatment approach on severe infection in patients with hematological diseases / 中国医师进修杂志
Chinese Journal of Postgraduates of Medicine
; (36): 297-300, 2018.
Article
in Zh
| WPRIM
| ID: wpr-700210
Responsible library:
WPRO
ABSTRACT
Objective To evaluate the efficacy and safety of tigecycline-based treatment approach on severe infection of patients with hematological diseases. Methods The clinical data of 64 patients who were treated with tigecycline-based treatment approach for severe infection were retrospectively reviewed. The curative effect was evaluated, meanwhile the drug side effects were observed. Results A total of 51 strains of bacteria were isolated from 64 patients, including 12 extended-spectrum β-lactamase(ESBL)and 15 multi-drug resistant strains and the total effective rate was 59.4%(38/64). Five patients diagnosed as carbapenem resistant infection and were treated with the addition dose of tigecycline and 3 patients relieved. Main adverse events were nausea, vomiting, diarrhea and hepatic dysfunction, but all events were slight. Conclusions Tigecycline-based treatment approach has a good clinical efficacy in treating severe infection of patients with hematological diseases, and the side effect is few.Tigecycline-based treatment approach could be used as a new choice for patients non-responding favorably to conventional anti-infective treatment or multiple resistant bacteria.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Postgraduates of Medicine
Year:
2018
Type:
Article