Correlation Between Cutaneous Adverse Reactions Caused by Aromatic Antiepileptic Drugs and Human Leukocyte Antigen Gene Polymorphism / 医药导报
Herald of Medicine
;
(12): 206-211, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-700985
ABSTRACT
Aromatic antiepileptic drugs such as carbamazepine are the first-line treatment for epilepsy. The adverse reactions have greatly limited their clinical application. The occurrence rate of severe skin adverse reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) is low,but they are often fatal.Human leukocyte antigen (HLA) gene polymorphisms are reported to be related with skin adverse reactions caused by aromatic antiepileptic drugs,but the exact mechanism is unclear.This article will perform a review about the correlation between skin adverse reactions caused by aromatic antiepileptic drugs and HLA gene polymorphisms published in recent years,in order to provide theoretical basis for further study of HLA susceptibility genes in Chinese Han population,and provide a reference for achieving individualized treatment of epilepsy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Herald of Medicine
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS