Effect of allopurinol on renal function in hyperuricemia patients complicated with chronic renal insufficiency / 中国基层医药

ABSTRACT

Objective To explore the effect of allopurinol on renal function in hyperuricemia patients complicated with chronic renal insufficiency.Methods From February 2015 to August 2017,100 hyperuricemia patients complicated with chronic renal insufficiency in the Affiliated Hospital of Hangzhou Normal University were selected as the study object,and they were randomly divided into observation group and control group according to the digital table,with 50 cases in each group.The observation group was treated with allopurinol,and the control group was not used allopurinol,The clinical indexes of the two groups before and after treatment were comparatively analyzed.Results The MAP[(102.8 ±22.2)mmH vs.(103.8 ±19.6)mmH],24h urinary protein[(2.5 ±1.4)g/d vs.(2.5 ±0.8)g/d],hemoglobin[(121.7 ±20.5)g/L vs.(120.7 ±26.9)g/L] and CRP[(6.8 ±1.9)mg/L vs.(6.4 ±2.0)mg/L] index in the observation groupbefore and after treatment had no statistically significant differences(t=1.253,0.223,3.1.052,1.324,all P>0.05),the serum uric acid [(449.8 ±154.7)μmol/L vs.(344.6 ± 124.7)μmol/L],serum creatinine[(147.8 ±53.4)μmol/L vs.(160.2 ±51.9)μmol/L] and eGFR[(44.4 ± 17.6)vs.(41.8 ±22.4)] were improved after treatment compared with those before treatment,and the differences were statistically significant(t=18.632,25.632,5.534,10.547,12.635,all P<0.05).Of the observation group and control group,the MAP were(103.4 ±19.5)mmHg,(105.8 ±23.2)mmHg,respectively and the 24h urine protein were(2.4 ±1.2)g/d,(2.4 ±1.2)g/d,respectively,and the hemoglobin were(120.8 ±22.4)g/L,(119.4 ± 25.8)g/L,respectively,and the CRP were(6.8 ±2.5)mg/L,(6.2 ±1.8)mg/L,respectively.and before and after treatment,there were no statistically significant differences(t=0.256,0.522,1.635,0.362,all P>0.05).The levels of serum uric acid [(468.7 ±114.9)μmol/L vs.(524.8 ±118.9)μmol/L],serum creatinine [(142.33 ± 50.2)μmol/L vs.(182.3 ±63.2)μmol/L] and eGFR [(44.7 ±14.5)vs.(37.2 ±21.8)] before treatment between the two groups had no statistically significant differences(all P>0.05).After treatment,the levels of serum uric acid[(344.6 ±124.7)μmol/L] and serum creatinine[(160.2 ±51.9)μmol/L] in the observation group were significantly lower than those in the control group [(524.8 ±118.9)μmol/L,(182.3 ±63.2)μmol/L]and the value of eGFR in the control group [(41.8 ±22.4)] was significantly higher than that in the control group [(37.2 ± 21.8)],the differences were statistically significant(t =10.635,26.352,8.041,all P <0.05).Conclusion Allopurinol not only can effectively protect the patient's kidneys,reduce the patients'blood uric acid levels,but also can effectively reduce the late glycosylated end products(which)levels.