Cardiovascular risk factors among dermatomyositis patients with positive anti-Jo-1 antibody / 中国免疫学杂志
Chinese Journal of Immunology
; (12): 407-411, 2018.
Article
in Zh
| WPRIM
| ID: wpr-702743
Responsible library:
WPRO
ABSTRACT
Objective:
To assess the association between anti-Jo-1 antibody and cardiovascular risk factors among patients with dermatomyositis (DM).Methods:
87 patients with DM were included from 2006 to 2013.Serum anti-Jo-1 antibody was measured by ELISA,and cardiovascular risk factors were evaluated.Multiple linear regression was used to assess the association between anti-Jo-1 antibody and cardiovascular risk factors in these patients.Results:
The prevalence of hypertension,diabetes,hyperuricemia,and dyslipidemia were 16.09%,22.99%,10.34% and 67.82%,respectively.16.09% of DM patients had a positive anti-Jo-1 antibody and these patients had higher frequency of arthralgia/Raynaud's phenomenon/interstitial lung disease,and higher level of leukocyte and C reactive protein,while had lower level of serum uric acid (P<0.05).Multiple linear regression demonstrated that anti-Jo-1 antibody was closely associated with the level of C reactive protein and serum uric acid.Conclusion:
Positive anti-Jo-1 antibody is associated with inflammation marker;however,the detailed mechanism remains further research.
Full text:
1
Index:
WPRIM
Type of study:
Etiology_studies
/
Risk_factors_studies
Language:
Zh
Journal:
Chinese Journal of Immunology
Year:
2018
Type:
Article