Safety and Efficacy of Chemical Ablation With Anhydrous Alcohol Combined With Gelatin Sponge for Patients With Hypertrophic Obstructive Cardiomyopathy / 中国循环杂志

ABSTRACT

Objectives:To analyze the safety and efficacy of chemical ablation of anhydrous alcohol combined with gelatin sponge for patients with hypertrophic obstructive cardiomyopathy (HOCM). Methods:The clinical data of 7 HOCM patients, who underwent chemical ablation with anhydrous alcohol and gelatin sponge in Fuwai Hospital from May 2017 to December 2017, were analyzed. Results:There were 5 males and 2 females, with a median age of 56 years (range, 43-67 years), the mean interventricular septum thickness was (19.6 ± 4.8) mm, the number of ablated septal branch was 1-2, the amount of used anhydrous alcohol was 1.4 (1.0-2.0) ml, the amount of applied gelatin sponge was 0.5 (0.1-1.3) ml. After procedure, the left ventricular outflow tract pressure was significantly decreased ([31.6 ± 12.6] mmHg vs [86.4 ± 20.7] mmHg, P＜0.001), NYHA cardiac function was significantly improved (1.4 ± 0.5 vs 2.7 ± 0.8, P ＜0.05), no relevant complications occurred. Conclusions:Chemical ablation with anhydrous alcohol and gelatin sponge is safe and effective for patients with hypertrophic obstructive cardiomyopathy.