Content Determination of 8 Metal Elements in Propylgaclate and Sodium Chloride Injection by Microwave Digestion-inductively Coupled Plasma Mass Spectrometry / 中国药房
China Pharmacy
; (12): 1612-1616, 2018.
Article
in Zh
| WPRIM
| ID: wpr-704854
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To establish a method for the content determination of 8 metal elements in Propylgaclate and sodium chloride injection.METHODS:
Microwave digestion-inductively coupled plasma mass spectrometry(ICP-MS) was adopted. Radiofrequency power was 1 530 W;cooling temperature was 4 ℃;collision gas was He gas;carrier gas was argon;flow rate of carrier gas was 1.08 L/min;integration time was 0.3 s;plasma gas flow rate was 15 L/min;the vacuum degree of quadrupole was 3.04×10-4 Pa;sampling cone aperture was 1.0 mm;interception cone aperture was 0.4 mm;the speed of sampling was 0.3 rps;data collection was repeated for 3 times. The microwave digestion power is 1 600 W,and the heating process is heated to 160℃at room temperature for 30 min,and maintained at 5 min,and then heated to 190 ℃ at a temperature of 5 ℃/min and maintained 45 min.RESULTS:
The linear range of Mg and Al were 1-250 ng/mL;the linear range of Cr,Mn,Fe,Cu,Zn,Cd were 1-100 ng/ mL(all r≥0.999 0). The limits of detection were 0.063 6-1.785 0 ng/mL. RSDs of precision,stability and reproducibility tests were all lower than 4%. The recoveries were 89.65%-105.60%(RSD were 1.57%-3.98%,n=9). RSDs of durablity were all lower than 12%.CONCLUSIONS:
The method is simple,accurate,precise,stable,reproducible and durable. It can be used for content determination of 8 metal elements in Propylgaclate and sodium chloride injection.
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
China Pharmacy
Year:
2018
Type:
Article