Pathogenesis of diabetic cognitive dysfunction and intervention by traditional Chinese medicine / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 303-308, 2018.
Article
in Zh
| WPRIM
| ID: wpr-705036
Responsible library:
WPRO
ABSTRACT
Diabetic cognitive dysfunction (DCD) is a common chronic complication of diabetes mellitus with sophisticated path-ogenesis which has not yet been fully elucidated. In this review paper, the mechanisms of metabolic abnormalities, insulin re-sistance,endoplasmic reticulum stress,neuronal calcium dysho-meostasis, in ammation, blood brain barrier impairment, and mitochondrial injury associated with DCD are reviewed. In addi-tion,the prevention and treatment of DCD by traditional Chinese medicines (TCMs) and the effective compounds are comprehen-sively summarized, in order to provide an updated overview on the DCD pathogenesis,as well as the scientific evidence under-pinning the use of TCM interventions for the treatment and pre-vention of DCD.
Full text:
1
Index:
WPRIM
Type of study:
Etiology_studies
Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
2018
Type:
Article