Determination of Six Heavy Metals in Iron Filings and Ferric Ammonium Citrate by Atomic Absorption Spectrophotometry / 中国药师

ABSTRACT

Objective:To establish an atomic absorption spectrophotometric method for the determination of 6 heavy elements in-cluding lead,cadmium,mercury, arsenic, copper and chromium in iron filings and ferric ammonium citrate in order to control the quality and ensure people's daily medicine safety.Methods:The determination method for lead,cadmium,chromium,copper,arse-nic and mercury was a graphite furnace method, a graphite furnace method, a graphite furnace method, a flame method, a hydride method and a cold steam absorption method,respectively. Results:The concentration of lead within the range of 0-50 ng·ml-1had a good linear relationship with the absorbance(r=0.999 8),and the average recovery was 98.9%(RSD=2.3%,n=6). The concen-tration of cadmium within the range of 0-4 ng·ml-1had a good linear relationship with the absorbance(r=0.999 1),and the average recovery was 90.5%(RSD=1.5%,n=6). The concentration of chromium within the range of 0-50 ng·ml-1had a good linear rela-tionship with the absorbance(r=0.999 7),and the average recovery was 96.1%(RSD=1.1%,n=6). The concentration of copper within the range of 0-800 ng·ml-1had a ood linear relationship with the absorbance (r=0.999 9), and the average recovery was 97.5%(RSD=1.2%,n=6). The concentration of arsenic within the range of 0-16 ng·ml-1had a good linear relationship with the absorbance (r=0.999 0),and the average recovery was 93.4%(RSD =1.1%, n =6). The concentration of mercury within the range of 0-18 ng·ml-1had a good linear relationship with the absorbance(r=0.999 2),and the average recovery was 93.2%(RSD=3.8%,n=6). Conclusion:The method with good repeatability is accurate,which can be used for the quality control of iron filings and ferric ammonium citrate.