Prenatal echocardiography in diagnosis of fetal cardiac tumors / 中国医学影像技术

ABSTRACT

Objective To observe the echocardiographic characteristics,genetic test and outcome of fetal cardiac tumors.Methods Echocardiographic data of 55 fetuses with cardiac tumors were retrospectively analyzed,and the echocardiographic characteristics were observed.Pathological and genetic test were performed on terminated fetuses.Peripheral blood was obtained from newborns for genetic test,and followed up was performed.Results In 55 fetuses with cardiac tumors,37 fetuses were terminated,7 fetuses were delivered and 11 fetuses were lost in follow-up.Solitary tumor was found in 14 fetuses,while multiple tumors were detected in 41 fetuses.Pathological examination was performed on 28 fetuses after termination,and 27 rhabdomyomas and 1 hemangioma were diagnosed.Fetal rhabdomyomas were found hyperechogenic,well demarcated and ovoid lesion,located at atrial and ventricular wall without blood flow with ultrasound.Tuberous sclerosis complex (TSC) genetic test was made in 24 terminated fetuses,and 19 positive and 5 negative results were obtained.In 7 newborns,spontaneous tumor regression occurred in 4 and tumor persistent in 3,while TSC genetic test positive in 2 and negative in 1 were detected.Conclusion Rhabdomyoma is the most common cardiac tumor in fetuses.Fetuses with multiple rhabdomyomas might be highly suspected of TSC,and then genetic test should be suggested.