Cutaneous adverse events caused byimmune checkpoint inhibitors:classification and management / 中华放射肿瘤学杂志

ABSTRACT

Immune checkpoint inhibitors(ICPIs)have been successfully used in the treatment of multiple malignancies.However,immune-related adverse events(irAEs)may occur during treatment.Cutaneous adverse event(CAE)is acommon type of irAE. Mild CAEs include maculopapule,lichenoid reaction,bullous pemphigoid,vitiligo,psoriasis,and scleroderma. Severe and even life-threatening CAEs include Steven-Johnson syndromeand toxic epidermal necrolysis. Other CAEs include drug reactionwith eosinophiliaand systemic symptoms,Sweet′s syndrome,alopecia,Grover′s disease, and paraneoplastic syndrome. This paper reviews the treatment of cutaneous adverse events associated with ICPIs.