Relationship between the level of serum CA125, prealbumin, cholinesterase and cirrhosis degree by Child-Pugh score / 中华老年医学杂志

ABSTRACT

Objective To evaluate the relationship between cirrhosis degree and the level of serum CA125,pre-albumin (PA) and cholinesterase (CHE) in aged patients with cirrhosis.Methods One hundred and fifty-five patients with liver cirrhosis admitted to the Second People's Hospital of Tongxiang from December 1st 2013 to December 1st 2015 were selected as the observation group.The age of the patient was 61～81 years,with an average age of (65.5±6.2) years.The degree of patient liver cirrhosis was graded by Child-Pugh (CP) score.Fifty healthy individuals from 60 to 79 years old,average (67.3±5.2) years were selected as the control group.Four indicators were detected in all research objects,including CA125,PA and CHE.Spearman correlation analysis was carried out between liver cirrhosis grading and each index changes.Results Compared to the healthy groups,the patients with liver cirrhosis had a higher levels of CA125,which was a positively correlated with cirrhosis degree.Patients with CP score A,B,C liver function had significantly different levels of CA125 [(43.55± 23.71) μg/L,(157.22 ± 57.18) μg/L,(261.28 ± 131.98) μg/L,respectively,F=102.33,P=0.000],PA [(176.81±55.18) mg/L,(135.23 ± 39.98) mg/L,(89.27 ±49.11) mg/L,respectively,F=177.61,P=0.000] and CHE [(4 727.46±998.10) U/L,(2 451.016±528.81) U/L,(1 962.58±439.14) U/L respectively,F=208.95,P=0.000].Patients with liver cirrhosis were associated with lower levels of PA and CHE than those in the healthy participants,which were negatively correlated with cirrhosis degree.Conclusions The CA125,PA and CHE have an important clinical significance in diagnosis,conditions' evaluation and prognosis' assessment for cirrhosis.