Evaluation of the safety and effectiveness of a postoperative intravenous injection of Dezocine on the recovery from emergency agitation in patients receiving radical resection of rectal carcinoma / 中华老年医学杂志

ABSTRACT

Objective To investigate the safety and effectiveness of a postoperative intravenous injection of Dezocine on the recovery from emergency agitation after Sevoflurane based anesthesia in patients receiving radical resection of rectal carcinoma.Methods A total of 66 patients receiving Sevoflurane Fentanyl anesthesia during radical resection of rectal cancer in our hospital from February 2015 to January 2017 were enrolled.They were randomly divided into a control group (normal saline,n=33) and an observation group (Dezocine,n 33).At 15 minutes before the end of operation,the control group received an intravenously administered normal saline,and the Dezocine group received 0.1 mg/kg dezocine in normal saline.The emergency agitation (EA),incidence of adverse reactions,and hemodynamic indexes were collected in both groups.Results The mean values of arterial blood pressure (MAP) and heart rate (HR) were significantly lower in the observation group than in control group at all four observation time points (tMAP =3.228,3.603,5.431,5.568;tHR =3.447,3.739,4.425,4.476;all P ＜0.05).The incidence of EA was significantly lower in the observation group (6.1％) than in the control group (24.2％) (x2=4.242,P=0.039).The stay time in post anesthesia care unit (PACU) was significantly shorter in the observation group [(54 ± 11) min] than in the control group [(72± 12) min] (t =9.317,P =0.000).In addition,the observation group had lower agitation scores and lower Ramsay sedation scores compared with the control group at all time points during extubation (tagitation =2.862,3.348,3.411,3.159;tRamsay =3.508,3.617,3.207,2.931;all P＜0.05).Conclusions The use of Dezocine during anesthesia recovery period in patients undergoing radical resection of rectal cancer has an analgesic effect.h can effectively reduce the incidence of EA and maintain hemodynamic stability.