Application of whole mount sections technique in the diagnosis of prostate cancer / 中华泌尿外科杂志
Chinese Journal of Urology
; (12): 761-765, 2018.
Article
in Zh
| WPRIM
| ID: wpr-709595
Responsible library:
WPRO
ABSTRACT
Objective To investigate the significance of whole mount sections after radical prostatectomy in the diagnosis of prostate cancer.Methods The data of 210 patients with radical prostatectomy in the Department of Urology of Northern Jiangsu People's Hospital from April 2018 to July 2015 were collected,of which 150 cases (control group) were examined with routine tissue section examination and 60 cases (study group) were examined with whole mount sections.The age of the study group and the control group were (69.0 ± 5.0) years and (70.0 ± 7.0) years respectively,and PSA was (18.8 ± 2.5) ng/ml and (19.3 ± 2.1) ng/ml respectively.The BMI of the study group was (23.0 ± 1.2) kg/m2,and the control group was (22.8 ± 0.6) kg/m2.The preoperative Gleason score of the study group and the control group were 7.9 ±0.9 and 7.7 ± 1.6 respectively.There were 137 patients (91.3%) with clinical stage cT1-T2 and 13 patients with cT3(8.7%) in control group.In the study group,there were 51 cases (85.0%) with clinical stage cT1-T2,and 9 cases with cT3 (15.0%).There was no significant difference between the two groups (P > 0.05) in term of the patients' demographics.The postoperative Gleason score,positive surgical margin,seminal vesicle invasion lymph node metastasis and pathological stage were compared between the two groups.Results The median prostate volume of the study group was 45.2 (18.3-121.5) ml,and 47.1 (2 1.3-124.2) ml in the control group.The operation time of the study group was 138.2 (119.5-234.1) mins,and 133.5 (116.8-228.2) mins in the control group.In the control group,there were 8 cases(5.3%) with seminal vesicle invasion,and 8 cases (5.3%) with lymph node metastasis.The pathological stages were pT2-T3 in 145 cases(96.7%),and pT4 in 5 cases (3.3%) in control group.The postoperative Gleason score was 8.0 ± 0.9 in control group.In the study group,17 patients (28.3%) with seminal vesicle invasion were pathologically indicated,and there were 6 patients (10.0%) with lymph node metastasis.The pathological stages were pT2-T3 of 57 cases(95.0%),and pT4 of 3 cases (5.0%),postoperative Gleason score was 7.7 ± 1.0 in study group.There was no statistically significant difference in seminal vesicle invasion,lymph node metastasis,pathological stage and postoperative Gleason score between the two groups (P > 0.05).There were 23 patients (15.3%) with positive margins in the control group,and 28 patients(46.7%) in the study group,which showed significant difference (P <0.01).For small lesions,there were 7 cases (4.7%) and 22 cases (36.7%) in the control group and the study group,respectively,which showed significant difference (P < 0.01).There were 17 cases (28.3%) of increased Gleason score in the study group,while 31 cases (20.7%) in the control group,with no statistical difference (P =0.232).Conclusions The whole mount section technique can effectively improve the positive surgical margin and the small lesions detection rate in the pathological evaluation of radical prostatectomy,and provide a precise pathological diagnosis for the postoperative treatment and follow-up of the patients.
Full text:
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Index:
WPRIM
Type of study:
Diagnostic_studies
Language:
Zh
Journal:
Chinese Journal of Urology
Year:
2018
Type:
Article