Clinical study on the effect of different calcineurin inhibitors on BK virus infection after renal transplantation / 中华器官移植杂志
Chinese Journal of Organ Transplantation
; (12): 1-6, 2018.
Article
in Zh
| WPRIM
| ID: wpr-710658
Responsible library:
WPRO
ABSTRACT
Objective To compare the effects of cyclosporine A (CsA) and tacrolimus (FK506) on BK virus infection after renal transplantation by retrospective clinical study.Methods The data of calcineurin inhibitor (CNI)-based immunosuppression and virus infection were collected in allograft renal transplantation recipients (n =135) from Jan.2014 to Dec.2015.According to the severity of the virus infection the recipients were divided into three groups:viruria,viremia and virus nephropathy.The difference in BK virus infection between FK506 and CsA was compared.Results A total of 135 cases of transplant recipients,postoperative were enrolled.The number of viruria recipients given FK506 and CsA was 41 cases (69.5%) and 18 cases (30.5%),and that of viremia recipients was 26 cases (86.7 %) and 4 cases (13.3 %).Statistical analysis showed that CNI immunosuppressive agents had a significant correlation with viremia only (P<0.05).There was a positive correlation between FK506 and viremia (r =0.423,P =0.018),and CsA showed a negative correlation yet (r =-0.336,P =0.022).Conclusion Tacrolimus is independent risk factors for early BK viremia after kidney transplantation,and CsA may inhibit the progression of BK viremia.
Full text:
1
Index:
WPRIM
Type of study:
Risk_factors_studies
Language:
Zh
Journal:
Chinese Journal of Organ Transplantation
Year:
2018
Type:
Article