Prognostic Implication of Telomerase Activity in Patients with Brain Tumors
Journal of Korean Medical Science
; : 126-130, 2006.
Article
in En
| WPRIM
| ID: wpr-71341
Responsible library:
WPRO
ABSTRACT
Telomerase adds telomeric repeats to the ends of telomeres to compensate for their progressive loss. A favorable prognosis is associated with low or no telomerase in some tumors. The authors investigated whether telomerase activity is associated with survival of patients with brain tumors. Sixty-two consecutive patients with brain tumors underwent surgery, and their surgical specimens were investigated. The patients were pathologically categorized as group I (aggressive group) and group II (non-aggressive group). Telomerase activity was examined by the telomeric repeat amplification protocol (TRAP) assay. The median time was calculated in association with overall survival and progression-free survival in each group. The significant difference was noted in telomerase activity between high-grade gliomas and lowgrade gliomas (p=0.022). Telomerase activity was significantly associated with the median overall survival and progression-free survival in all tumors of the aggressive group. On the other hand, the median overall survival in the non-aggressive group was not dependent on telomerase activity, while the median progression-free survival was. Our data suggests that telomerase is an important prognostic indicator of survival in patients with brain tumors.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Prognosis
/
Brain Neoplasms
/
Enzyme-Linked Immunosorbent Assay
/
Survival Analysis
/
Polymerase Chain Reaction
/
Telomerase
Type of study:
Prognostic_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2006
Type:
Article