Correlations of Four Genetic Single Nucleotide Polymorphisms in Brain-Derived Neurotrophic Factor with Posttraumatic Stress Disorder
Psychiatry Investigation
; : 407-412, 2018.
Article
in En
| WPRIM
| ID: wpr-714291
Responsible library:
WPRO
ABSTRACT
OBJECTIVE: To investigate the correlations of four genetic single nucleotide polymorphisms (SNPs) of brain-derived neurotrophic factor (BDNF) with posttraumatic stress disorder (PTSD). METHODS: A total of 300 patients with sporadic PTSD and 150 healthy subjects (the control group) were selected according to the diagnostic criteria of PTSD (DSM-IV), and the genotypes of the BDNF SNPs G-712A, C270T, rs6265, and rs7103411 were detected by polymerase chain reaction and direct DNA sequencing to determine intergroup differences in the genotypes and allele frequencies; the p values were corrected with the permutation test. RESULTS: The genotypes and allele frequencies of the SNPs G-712A, rs6265, and rs7103411 of BDNF showed no significant intergroup differences (p>0.05). However, the genotype and allele frequencies of C270T showed significant differences between the PTSD group and the control group (p<0.05). CONCLUSION: The SNP C270T of BDNF may be associated with PTSD. Individuals carrying the polymorphic T allele of C270T may be more likely to suffer from PTSD.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Stress Disorders, Post-Traumatic
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Polymerase Chain Reaction
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Sequence Analysis, DNA
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Brain-Derived Neurotrophic Factor
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Polymorphism, Single Nucleotide
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Alleles
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Healthy Volunteers
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Gene Frequency
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Genotype
Limits:
Humans
Language:
En
Journal:
Psychiatry Investigation
Year:
2018
Type:
Article