Interleukin-1beta promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways
Experimental & Molecular Medicine
;
: 757-764, 2009.
Article
in English
| WPRIM
| ID: wpr-71507
ABSTRACT
Monocyte chemoattractant protein-1 (MCP1) plays a key role in monocyte/macrophage infiltration to the sub-endothelial space of the blood vessel wall, which is a critical initial step in atherosclerosis. In this study, we examined the intracellular signaling pathway of IL-1beta-induced MCP1 expression using various chemical inhibitors. The pretreatment of a phosphatidylcholine (PC)-specific PLC (PC-PLC) inhibitor (D609), PKC inhibitors, or an NF-kappaB inhibitor completely suppressed the IL-1beta-induced MCP1 expression through blocking NF-kappaB translocation to the nucleus. Pretreatment with inhibitors of tyrosine kinase or PLD partially suppressed MCP1 expression and failed to block nuclear NF-kappaB translocation. These results suggest that IL-1beta induces MCP1 expression through activation of NF-kappaB via the PC-PLC/PKC signaling pathway.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aorta
/
Phospholipases
/
Pyrrolidinones
/
Thiones
/
Protein-Tyrosine Kinases
/
Recombinant Proteins
/
Bridged-Ring Compounds
/
Signal Transduction
/
Cell Nucleus
/
Cells, Cultured
Limits:
Humans
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2009
Type:
Article
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