Interleukin-1beta promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways
Experimental & Molecular Medicine
; : 757-764, 2009.
Article
in En
| WPRIM
| ID: wpr-71507
Responsible library:
WPRO
ABSTRACT
Monocyte chemoattractant protein-1 (MCP1) plays a key role in monocyte/macrophage infiltration to the sub-endothelial space of the blood vessel wall, which is a critical initial step in atherosclerosis. In this study, we examined the intracellular signaling pathway of IL-1beta-induced MCP1 expression using various chemical inhibitors. The pretreatment of a phosphatidylcholine (PC)-specific PLC (PC-PLC) inhibitor (D609), PKC inhibitors, or an NF-kappaB inhibitor completely suppressed the IL-1beta-induced MCP1 expression through blocking NF-kappaB translocation to the nucleus. Pretreatment with inhibitors of tyrosine kinase or PLD partially suppressed MCP1 expression and failed to block nuclear NF-kappaB translocation. These results suggest that IL-1beta induces MCP1 expression through activation of NF-kappaB via the PC-PLC/PKC signaling pathway.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Aorta
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Phospholipases
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Pyrrolidinones
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Thiones
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Protein-Tyrosine Kinases
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Recombinant Proteins
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Bridged-Ring Compounds
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Signal Transduction
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Cell Nucleus
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Cells, Cultured
Limits:
Humans
Language:
En
Journal:
Experimental & Molecular Medicine
Year:
2009
Type:
Article