Prognostic Value of Baseline ¹⁸F-Fluorodeoxyglucose PET/CT in Patients with Multiple Myeloma: A Multicenter Cohort Study
Korean Journal of Radiology
;
: 481-488, 2018.
Article
in English
| WPRIM
| ID: wpr-715443
ABSTRACT
OBJECTIVE:
We investigated the prognostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in patients with multiple myeloma (MM). MATERIALS ANDMETHODS:
Subjects were 76 patients with newly diagnosed myeloma and pretreatment with 18F-FDG PET/CT from four hospitals. The PET/CT features were evaluated and the clinical characteristics were reviewed. Prognostic factors related to poor progression-free survival (PFS) and overall survival (OS) were identified using a Cox proportional hazards regression model and a prediction scale was developed based on the identified factors.RESULTS:
Multivariate analysis showed that the presence of 18F-FDG-avid focal bone lesions (≥ 3) was a significant and independent predictor of PFS (hazard ratio [HR] = 3.28, p = 0.007) and OS (HR = 11.78, p = 0.001). The presence of extramedullary disease on PET/CT scan was also a significant predictor of poor PFS (HR = 2.79, p = 0.006) and OS (HR = 3.89, p = 0.003). A prognostic scale was developed using these two predictors. An increase in score on the scale corresponded to a significantly increased risk of poor OS (p = 0.005). In addition, Kaplan-Meier analysis demonstrated that patient survival varied significantly according to the scale (p < 0.001 for OS and p = 0.001 for PFS).CONCLUSION:
18F-FDG-avid focal lesions and the presence of extramedullary disease on PET/CT scan are significantly associated with poor OS in MM patients. The scale developed according to these predictors represents a potential prognostic tool for evaluation of patients with MM.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Multivariate Analysis
/
Cohort Studies
/
Disease-Free Survival
/
Fluorodeoxyglucose F18
/
Electrons
/
Kaplan-Meier Estimate
/
Positron Emission Tomography Computed Tomography
/
Multiple Myeloma
Type of study:
Controlled clinical trial
/
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Korean Journal of Radiology
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS