Ubiquitin C-terminal Hydrolase L1 Regulates Lipid Raft-dependent Endocytosis
Experimental Neurobiology
;
: 377-386, 2018.
Article
in English
| WPRIM
| ID: wpr-717414
ABSTRACT
Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is highly expressed in neurons, and gathering evidence indicates that UCH-L1 may play pathogenic roles in many neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease (PD). Additionally, lipid rafts have attracted interest in neurodegeneration as playing a common role in many neurodegenerative diseases. In the present study, we demonstrated that UCH-L1 associates with lipid rafts as with other PD-associated gene products. In addition, UCH-L1 regulates lipid raft-dependent endocytosis and it is not dependent on the expression and degradation of caveolin-1 or flotillin-1. Finally, UCH-L1 regulates cell-to-cell transmission of α-synuclein. This study provides evidence that many PD-associated gene products share common signaling pathways to explain the pathogenesis of PD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parkinson Disease
/
Prion Diseases
/
Neurodegenerative Diseases
/
Ubiquitin
/
Ubiquitin Thiolesterase
/
Endocytosis
/
Caveolin 1
/
Alpha-Synuclein
/
Alzheimer Disease
/
Neurons
Language:
English
Journal:
Experimental Neurobiology
Year:
2018
Type:
Article
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