Effect of Blood Donation on the Donor's Hemorheological Properties / 대한수혈학회지
Korean Journal of Blood Transfusion
; : 229-239, 2018.
Article
in Ko
| WPRIM
| ID: wpr-718922
Responsible library:
WPRO
ABSTRACT
The circulatory system is closely related to the inter-relationship between the anatomy of the heart and blood vessels, and the fluid dynamic properties of blood. The physical properties of blood, which affect blood flow, are called hemorheologic factors. Hemorheologic factors, such as blood viscosity and erythrocyte aggregation, are influenced mainly by hematocrit. A higher hematocrit level results in an increase in blood viscosity, erythrocyte aggregation, which impedes the circulation itself, and tissue oxygenation. An excess of serum ferritin causes injury to vascular endothelial cells and erythrocytes via oxygen free radicals. In addition, an excess of blood can aggravatee the adverse effects of the hemorheologic parameters and induce atherogenesis, microcirculatory disturbances, and major cardiovascular events. A preventive and therapeutic approach with a phlebotomy or blood donation has been stimulated by the knowledge that blood loss, such as regular donations, is associated with significant decreases in key hemorheologic variables, including blood viscosity, erythrocyte aggregation, hematocrit, and fibrinogen. Major cardiovascular events have been improved in regular blood donors by improving blood flow and microcirculation by decreasing the level of oxidative stress, improving the hemorheologic parameters, and reducing the serum ferritin level. Confirmation of the positive preventive and therapeutic effects of blood donations on cardiovascular disease by a well-designed and well-controlled Cohort study may be good news to patients with cardiovascular disease or at risk of these diseases, as well as patients who require a transfusion.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Oxygen
/
Blood Donors
/
Blood Vessels
/
Blood Viscosity
/
Fibrinogen
/
Cardiovascular Diseases
/
Cohort Studies
/
Oxidative Stress
/
Phlebotomy
/
Endothelial Cells
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Humans
Language:
Ko
Journal:
Korean Journal of Blood Transfusion
Year:
2018
Type:
Article