A Randomized Clinical Trial of Synbiotics in Irritable Bowel Syndrome: Dose-Dependent Effects on Gastrointestinal Symptoms and Fatigue / 가정의학회지
Korean Journal of Family Medicine
; : 2-8, 2019.
Article
in En
| WPRIM
| ID: wpr-719540
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
This double-blind, randomized controlled design study aimed to assess the dose-dependent effects of synbiotics on gastrointestinal symptoms of and fatigue in irritable bowel syndrome (IBS).METHODS:
Thirty subjects with IBS were randomly assigned into the following three groups and received 2 capsules a day for 8 weeks (1) high-dose (2 capsules of synbiotics); (2) low-dose (1 capsule of synbiotics and 1 capsule of placebo); and (3) placebo (2 capsules of placebo). At baseline and 8 weeks, they completed the study questionnaires.RESULTS:
Two subjects in the high-dose group were lost to follow-up, leaving a total of 28 patients for the analysis. After 8 weeks, abdominal discomfort, abdominal bloating, frequency of formed stool, fatigue Visual Analog Scale (VAS), and Multidimensional Fatigue Inventory were significantly different among the groups (P=0.002, 0.006, 0.007, 0.028, and 0.041, respectively, by Kruskal-Wallis test). However, only abdominal discomfort, abdominal bloating, frequency of formed stool, and fatigue VAS were significantly improved in the high-dose group compared with those in the placebo group (P=0.002, 0.003, 0.002, and 0.013, respectively) by Mann-Whitney test with Bonferroni correction. No adverse drug reactions were reported.CONCLUSION:
High-dose synbiotics were superior to placebo in improving bowel symptoms and fatigue of IBS patients, suggesting that synbiotic dosage plays an important role in the treatment of IBS.Key words
Full text:
1
Index:
WPRIM
Main subject:
Capsules
/
Probiotics
/
Irritable Bowel Syndrome
/
Drug-Related Side Effects and Adverse Reactions
/
Fatigue
/
Lost to Follow-Up
/
Synbiotics
/
Visual Analog Scale
Type of study:
Clinical_trials
/
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Korean Journal of Family Medicine
Year:
2019
Type:
Article