A Case of Heparin Induced Thrombocytopenia with Circulating Anti-PF4/Heparin Antibody
Korean Journal of Hematology
; : 67-70, 2007.
Article
in Ko
| WPRIM
| ID: wpr-720134
Responsible library:
WPRO
ABSTRACT
Heparin-induced thrombocytopenia (HIT) is usually caused by anti-platelet factor 4 (PF4)/heparin antibodies, leading to intravascular platelet activation. Circulating anti-PF4/heaprin antibody (IgG, IgA and IgM) was detected by ELISA (Asserachrom HPIA, Diagnostia Stago, Asnieres, France) in a 61-yearold man with coronary artery disease and dyspnea on exercise. He had undergone a coronoary angiography using 2,000 unit of heparin before a procedure. On admission, laboratory testing revealed a platelet count of 296x10(9)/L and aPTT (activated partial thromboplastin time) of 38.1 sec. The fall in the platelet count was progressive, resulting in 42% and 53% of platelet counts on the 6th and 12th days after intravenous heparin administration, respectively. He was discharged after coronary artery bypass graft. On discharge, platelet count was normalized to be 212x10(9)/L. On the 7th day after dischage, anti-PF4/heaprin antibody was detected by ELISA (Asserachrom HPIA, Diagnostia Stago, Asnieres, France).
Key words
Full text:
1
Index:
WPRIM
Main subject:
Platelet Count
/
Thrombocytopenia
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Coronary Artery Disease
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Immunoglobulin A
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Thromboplastin
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Enzyme-Linked Immunosorbent Assay
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Angiography
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Heparin
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Platelet Activation
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Coronary Artery Bypass
Language:
Ko
Journal:
Korean Journal of Hematology
Year:
2007
Type:
Article